FORMULATION DEVELOPMENT AND CHARACTERIZATION OF LAFUTIDINE RAFT SYSTEM

Objective: The present research work is focused to develop in situ raft gel of lafutidine. Sodium alginate one the critical components for development system. Methods: formulation was prepared using hydrophilic polymers such as ethyl cellulose, HPMC K4M, and chitosan. formulations were subjected evaluation characteristics pH, vitro gelling time, viscosity, density, strength, drug-polymer compatibility studies, drug content floating lag swelling index, release studies. Results: pH all batches found range 5.7 7.6. All showed viscosity 264 320 cps, with time from 4-7 s. For F1-F15 Floating be 9-24 sec. Densities stomach specific gels 0.4 0.8 gm/cm3. highest index observed F15 14.16% Highest strength exhibited by F15; 95.46–99.95, indicating uniform distribution drug. Formulation containing chitosan combination cellulose gave 99.78% also sustained controlled up 24h. Conclusion: shows an R2 value 0.999. As its nearer ‘1’ it confirmed follows Zero order ‘n’ 1.5021 optimized (F15) i.e., n indicates super case II transport considered formulation.